Safe Drug Combo May Reduce Post Surgical Cancer Recurrence

surgeon-PhalinnOoi-flickr.jpg

Researchers at Tel Aviv University (TAU) discovered a safe, cost-effective drug regimen that may significantly reduce post-surgical cancer recurrence.

The drug regimen includes a beta blocker that lowers blood pressure and relieves stress, and an anti-inflammatory. The medications are given a few days prior to, the day of, and several days following cancer surgery.

“We've taken an unconventional approach, deviating from the current medical dogma that refrains from intervening during the short period surrounding a cancer surgery - no chemo, radio or immune therapy for at least three weeks before or after surgery,” said Shamgar Ben-Eliyahu, a professor at TAU.

For the study 38 breast cancer patients were given the beta-blocker Deralin, and an anti-inflammatory called Etopan five days before their surgery, the day of surgery, and five days afterward. Samples of their blood and tumor tissues were analyzed to identify RNA expression in malignant cells and leukocytes.

The analysis showed the drugs effectively reduced biomarkers for cancer recurrence. “For example, we found that the drug treatment reverses EMT - the process that tumor cells go through to slip out of the primary tumor and enter another organ,” says Ben-Eliyahu. “We also looked at indices related to the immune system and were able to improve immune competence and reduce inflammation with the drugs.”

The Tel Aviv team did a separate study involving colorectal cancer patients, and the results were similar. Larger clinical trials looking at the long term benefits of the drug treatment are being considered.

“Positive outcomes should validate this treatment and lead to its becoming available for most cancer patients,” said Ben-Eliyahu.

Source: AFTAU
Photo credit: Phalinn Ooi


 
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